Since 9/11, the controversial thesis of Clash of civilizations by Samuel P. Huntington has been central to the debate to narrate the conflict between Islamic World and America. The conservative political academic has identified culture and religion as a primary source of conflict in the postCold War era. In his thesis, he identified two threats to the United States of America in 21st century: Islam and China. The identified threats have been based on civilizational fault lines lacking to consider raison d’état, interest of the state. This article will look at the interests of American as a global hegemon in the Islamic World whether they are geographical, political, economic, or military in nature since the Cold War; and how the pursuit of these interests has led to a clash based on interests. To secure national interests, American foreign policy has been aimed at war on terror, regime change and supporting authoritarian, undemocratic, and repressive regimes leading to a new threat − the rise of Radical Islam. The essay will evaluate the rise of radical Islam as a result of American Foreign policy and its geopolitical interests after 9/11 in the Islamic World